chromosomal abnormality

USAGE SUMMARY

The phrase "chromosomal abnormality" is correct and usable in written English.
It can be used in contexts related to genetics, biology, or medical discussions when referring to a deviation from the normal structure or number of chromosomes. Example: "The genetic test revealed a chromosomal abnormality that could explain the patient's symptoms."

✓ Grammatically correct

Science

News & Media

Encyclopedias

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

Loss of the Y chromosome is a common chromosomal abnormality observed in the human prostate cancer.

BMC Genomics

The inheritance of beta thalassemia is an autosomal recessive disorder with the chromosomal abnormality on short arm of 11th chromosome (chromosome # 11p15.5).

Progress in Orthodontics

Deletion of chromosome 13q14 is the most frequent chromosomal abnormality in this disorder.

EMBO Molecular Medicine

An odds ratio (OR) larger than one indicates that the chromosomal abnormality increases the chance of an abnormal clinical parameter.

American Journal of Hematology

This chromosomal abnormality results from a reciprocal translocation between the chromosome 9 and chromosome 22 [t(9 22)(q34;q11)].

Bioscience Reports

If OR is less than one, then the chromosomal abnormality decreases the chance of having an abnormal clinical parameter.

American Journal of Hematology

We knew, for instance that a chromosomal abnormality existed in every C.M.L. patient.

The New York Times - Science

"He said, 'There are a few things which could mean Seb has a chromosomal abnormality,'" Caroline recalls.

The Guardian

No chromosomal abnormality was found, and six and a half months later she gave birth to a healthy boy.

The New York Times - Health

A child is now more likely to have autism than Down syndrome, a detectable chromosomal abnormality causing mental retardation.

The New York Times

Androgyny rules in "Zerophilia," Martin Curland's audacious feature about a fictional chromosomal abnormality that wreaks havoc with one's genitals.

The New York Times

Expert writing Tips

Best practice

When writing about "chromosomal abnormalities", specify the exact type of abnormality (e.g., trisomy 21, translocation) whenever possible to provide more clarity and precision.

Common error

Avoid using "chromosomal abnormality" interchangeably with "genetic mutation". While all chromosomal abnormalities are genetic, not all genetic mutations are chromosomal.

Linguistic Context

The phrase "chromosomal abnormality" functions primarily as a noun phrase, often serving as the subject or object of a sentence. It identifies a specific type of genetic condition, as evidenced by the examples in Ludwig, where it's used to describe various medical conditions and genetic research findings. Ludwig AI confirms that this is usable in written English.

Expression frequency: Very common

Frequent in

Science

79%

News & Media

19%

Encyclopedias

2%

Less common in

Formal & Business

0%

Wiki

0%

Reference

0%

Ludwig's WRAP-UP

In summary, the term "chromosomal abnormality" is a noun phrase used to describe deviations in chromosome structure or number. It's grammatically sound and, according to Ludwig AI, is appropriate for use in formal English. The phrase is very common, especially in scientific and medical contexts, as evident in the analysis of numerous examples from sources like scientific journals, news outlets, and encyclopedias. This term is authoritative and widely used for classifying genetic conditions. Alternative phrases, such as "genetic anomaly" and "chromosomal aberration", offer nuanced variations in meaning, and it is vital to understand what distinguishes "chromosomal abnormalities" from the broader scope of all "genetic mutations".

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

chromosome anomaly

A simple swap of words, maintaining the same meaning.

chromosomal aberration

A more formal and scientific synonym for "chromosomal abnormality".

chromosome disorder

Replaces "abnormality" with "disorder", offering a slightly different connotation.

chromosomal defect

Uses "defect" instead of "abnormality", implying a flaw in the chromosome structure.

genetic anomaly

Focuses on the genetic aspect of the abnormality, rather than the chromosomal.

karyotypic abnormality

More technical term referring specifically to abnormalities in the karyotype (chromosome set).

structural chromosome change

More descriptive, specifying that the abnormality involves the structure of the chromosome.

numerical chromosome change

Highlights changes that affect the number of chromosomes present.

genetic mutation

Broader term encompassing changes in the genetic material, not necessarily chromosomal.

aneuploidy

Specific type of chromosomal abnormality involving an abnormal number of chromosomes.

FAQs

How is "chromosomal abnormality" detected?

Chromosomal abnormalities can be detected through various tests, including karyotyping, FISH (fluorescence in situ hybridization), and chromosomal microarray analysis. These tests analyze the number and structure of chromosomes in a sample.

What are some common examples of "chromosomal abnormalities"?

Common examples include Down syndrome (trisomy 21), Turner syndrome (monosomy X), and Klinefelter syndrome (XXY). These conditions involve alterations in the number or structure of chromosomes.

What can I say instead of "chromosomal abnormality"?

You can use alternatives like "genetic anomaly", "chromosome disorder", or "chromosomal aberration" depending on the context.

Is every "chromosomal abnormality" inherited?

Not all chromosomal abnormalities are inherited. Some occur spontaneously during the formation of egg or sperm cells, or during early development. Others can be inherited from a parent who carries a balanced translocation or other chromosomal rearrangement.