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This information will be helpful when choosing endpoints to measure in clinical studies and help provide a mechanistic explanation for when changes are observed or not.
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Ambivalence of cytokine function, differences in study designs, treatment regimens and chosen endpoints hamper the translation of experimental research into clinical practice.
The study designs and the chosen endpoints were often blamed for inadequacy, being at least in part responsible for study failures.
Using our chosen endpoints, SMC do not damaged by the MNPs. Figure 8 The TNF-α level in the supernate of SMC incubated with DMSA-MNPs.
Since the experimental protocol was designed for all animals to survive, we chose endpoints reflective of the degree of shock reversal.
The authors believe that a broad perspective must be applied to the endpoints of oncological studies and the chosen endpoints from the clinical trial should be recognized in the EBA in individual cases.
Mitogen stimulation assays are restricted to certain cell types and the chosen endpoints, while any compound-induced alteration is likely to be detected in a functional assay like the in vitro antibody response, when several immunocompetent cells have to cooperate to result in the humoral response analyzed.
The discrepancy with the positive findings in the study of Yip and colleagues might be explained by the chosen endpoints.
A well-designed study requires precise inclusion and exclusion criteria, guidelines on standardized steroid dosing, and carefully chosen endpoints.
To meet the user's demands in terms of readability an easy report systematic was chosen, endpoints and (possible) external factors were mostly quoted as binarized.
The choice of criterion should be driven by consideration of an acceptable false-positive rate which could be estimated through simulations taking into account the correlations among the chosen endpoints and assuming no treatment effect.
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