Sentence examples for cholesterol overloading from inspiring English sources
Moreover, Rh2-induced Fas oligomerization was abolished following cholesterol overloading, and Rh2-induced apoptosis was inhibited following treatment with siRNA for Fas.
Since cholesterol overloading, which fortifies lipid rafts, prevented an increase in Rh2-induced membrane fluidity, caveolin-1 internalization and apoptosis, lipid rafts appear to be essential for Rh2-induced apoptosis.
The intracellular trafficking of sphingolipid analogs is also known to be affected by cholesterol overloading of mammalian fibroblasts and neurons [12].
Similarly, the treatment of islets with methyl-β-cyclodextrin or mevastatin increases GSIS, whereas cholesterol overloading reduces GSIS (23).
Cholesterol overload often happens to adult neurons, because they primarily rely on exogenous cholesterol, whereas astrocytes produce cholesterol in excess to satisfy adult neurons' functional needs.
In summary, it appears that SBD trafficking is strongly influenced by cellular cholesterol levels, especially cholesterol overload, and this may reflect an underlying event involving the trafficking of its glycosphingolipid partner(s).
Under cholesterol overload (shown by filipin staining in and around endolysosomal compartments; fig. 9C) SBD was actually endocytosed more readily (quantification in fig. S6), but trafficking was strongly perturbed.
This indicates that neither depletion of total cellular cholesterol levels nor cholesterol overload are a likely cause of cell death observed in breast cancer cell lines, in particular because activation of SREBP-2 was also observed in the relatively resistant MCF10A cells (Figure S2).
Uptake of modified lipoproteins by macrophages in the vasculature leads to cholesterol overload and formation of atherogenic foam cells [ 13].
p53 has been suggested to help adipocytes handle the effects of lipid and cholesterol overload, thereby maintaining adipocyte viability (Bazuine et al., 2009).
On the other hand, owing to the cholesterol overload, foam cells eventually undergo apoptosis resulting in the accumulation of apoptotic cells that compete for the uptake by macrophages.
