Sentence examples for cholesterol overload from inspiring English sources
Cholesterol overload often happens to adult neurons, because they primarily rely on exogenous cholesterol, whereas astrocytes produce cholesterol in excess to satisfy adult neurons' functional needs.
For those aiming for complete cholesterol overload there were great dessert picks: a creamy cheesecake, whipped cream-topped Key lime pie, rich chocolate velvet cake and the even better Godiva hot chocolate cake with a runny center.
Finally, to further investigate the consequences of late endosomal cholesterol overload, we made use of Vesicular Stomatitis Virus (VSV), which infects cells from endosomes.
The effectiveness of the MβCD depletion and cholesterol overload was confirmed (40% reduction in total cholesterol after MβCD depletion; 250%, ±13% increase after overload; see [51]).
In summary, it appears that SBD trafficking is strongly influenced by cellular cholesterol levels, especially cholesterol overload, and this may reflect an underlying event involving the trafficking of its glycosphingolipid partner(s).
Under cholesterol overload (shown by filipin staining in and around endolysosomal compartments; fig. 9C) SBD was actually endocytosed more readily (quantification in fig. S6), but trafficking was strongly perturbed.
Moreover, Rh2-induced Fas oligomerization was abolished following cholesterol overloading, and Rh2-induced apoptosis was inhibited following treatment with siRNA for Fas.
Since cholesterol overloading, which fortifies lipid rafts, prevented an increase in Rh2-induced membrane fluidity, caveolin-1 internalization and apoptosis, lipid rafts appear to be essential for Rh2-induced apoptosis.
The intracellular trafficking of sphingolipid analogs is also known to be affected by cholesterol overloading of mammalian fibroblasts and neurons [12].
Similarly, the treatment of islets with methyl-β-cyclodextrin or mevastatin increases GSIS, whereas cholesterol overloading reduces GSIS (23).
ACAT1/SOAT1 becomes active in astrocytes under conditions like lacking apoE and when exogenous cholesterol is overloaded (Karten et al., 2006).
