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Abnormal cellular cholesterol handling in islets may contribute to β-cell dysfunction in type 2 diabetes.
Exogenous NPC2 protein is taken into cells via two mannose 6 phosphate receptors that are ubiquitously present in the membrane [7] and corrected the abnormality of cholesterol handling in fibroblasts from a patient with NPC2 mutation [2].
Thus, altered cholesterol handling by macrophages may in part explain how CLA mediates its atheroprotective effect.
In macrophages, LXR signaling modulates cholesterol handling and the inflammatory response, pathways involved in atherosclerosis.
Lipid and cholesterol handling, both in the intestinal lumen and for transport via CM and other lipoproteins, requires PL.
Our data extend these findings and suggest that cholesterol handling may also be a determinant of β-cell function in humans.
Similar(53)
Observation of diffusing DNA origami structures that were specifically attached to the cholesterol handles was crucially dependent on buffer composition.
After 1 h of incubation and several washing steps, we observed adherence and two-dimensional diffusion of DNA origami structures in membranes that were prepared with the cholesterol handles.
In control experiments with lipid membranes that lacked such cholesterol handles, in contrast, DNA structures did not adhere and the fluorescent objects moved in and out of the focal plane instead.
In any method of oxysterol analysis products formed by non-enzymatic autoxidation of cholesterol during sample storage, handling and workup can complicate reliable identification and quantification.
The risk factor recording was analysed in a linear regression model, while the dichotomous outcomes, antiplatelet therapy, influenza vaccination, blood pressure and cholesterol levels were handled in binomial logistic regression models.
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