Sentence examples for cholesterol excess from inspiring English sources

This suggests that cholesterol excess at the membrane and in endolysosomal compartments labelled by LAMP-GFP (fig. 9C) may shunt SBD away from a sorting compartment prematurely into acidic vesicles, and thereafter divert it away from the lysosomal pathway.

For cholesterol excess, 10 mM MβCD:10 mM cholesterol complexes were prepared as in Klein, et al[102] and incubated with cells at 25°C for 30 min before labelling.

Nevertheless, the later derangement was not limiting, as correction of membrane cholesterol excess mitigated cytoskeletal dysfunction and GLUT4 responsiveness, while signalling remained impaired.

These two 'extreme' metabolic conditions (GDM and familial hypercholesterolaemia), in conjunction with the results in the non-pregnant population relating high lipid levels to oxidative stress and endothelial dysfunction, suggest that lipid abnormalities arising from NEFA or cholesterol excess may be responsible for the observed endothelial dysfunction of obese pregnancy.

They tend to have fewer coronary risk factors like high blood pressure, high cholesterol or excess weight.

When macrophages take up cholesterol any excess not required for membrane homeostasis or other functions is esterified by ACAT and stored in ester form.

Control and reduction of cardiovascular risk factors such as elevated blood pressure, high cholesterol levels, excess of body weight, smoking and lack of exercise can contribute to a reduction of CVD mortality.

Studies have proven that control and reduction of cardiovascular risk factors such as elevated blood pressure, high cholesterol levels, excess of body weight, smoking and lack of exercise can contribute to a reduction of CVD mortality of around 40-60% [ 1].

This was unexpected since, under excess cholesterol, the cholesterol feedback loop should prevent proteolytic cleavage and activation of SREBP2.

Conversion of macrophages to lipid laden foam cells as a result of excess cholesterol uptake or defective cholesterol efflux is implicated in lesion development[6].

We found that 27-hydroxycholesterol, 22- hydroxycholesterol and 24- hydroxycholesterol levels were increased in cholesterol-fed rabbit retinas providing evidence that elimination of excess cholesterol to oxysterols takes place in the retina.