We observed significantly higher risk (HR 1.88, 95 CI 1.08-3.27, p-value 0.03) of developing high grade disease among men in the highest cholesterol category (combination of 4th and 5th quintile).
Each cholesterol category was considered to be managed if documentation of any of the following was found: (a) the need to recheck an abnormal cholesterol level; (b) discussion of lifestyle modifications; or (c) prescription or adjustment of cholesterol-lowering agents.
Tests of interactions between characteristics and glycaemia intervention: P=0.0405 for education; P=0.0010 for any insulin use; P=0.0090 for baseline haemoglobin A1C concentration; and P=0.0013 for low density lipoprotein cholesterol category.
In the fitted regression model, the cholesterol categories were treated as an indicator variable, with the lowest category as a reference group.
The composite simplified coronary prediction model built on the blood pressure and cholesterol categories proposed by the Joint National Committee on Blood Pressure and the National Cholesterol Education Program was used.
We evaluated the risk equations for predicting an initial CHD event using total cholesterol categories and referred to it as Framingham-initial.
We defined diastolic blood pressure categories as low (<80 mmHg), high (>80 mmHg), and unknown (28) and total cholesterol categories as low (up to 5 mmol/L), high (>5 mmol/L), and unknown (29).
In a 25-year follow-up study of 44 864 men with measured serum cholesterol levels, the testicular cancer hazard ratios for the serum cholesterol categories 5.7 6.9 and ⩾7.0 mmol l−1 vs the reference category (<5.7 mmol l−1) were 1.3 and 4.5, respectively; P-value for trend=0.005.
A positive correlation between serum cholesterol level and testicular cancer incidence was found and the estimated HRs for the middle and highest serum cholesterol categories compared to the lowest was 1.395%5% CI: 0.3 5.1) and 4.5 (95% CI: 1.3 16.2), respectively (P=0.005) (Table 1).
a Adjusted for age, sex, race/ethnicity, prior CVD, systolic or diastolic blood pressure, use of antihypertensive medications, diabetes status, smoking status, body mass index, cholesterol, CRP category and albumin-to-creatinine ratio category.
Hazard ratios (HR) were calculated to assess risk of death after adjustment for age, race/ethnicity, sex, body mass index, systolic and diastolic BP, antihypertensive medication use, history of diabetes and CVD, smoking status, serum total cholesterol, ACR categories and CRP categories.
