Such synthetic tumor-targeting receptors provide a choice of specificity and controlled T cell activation that is mainly attributed to extracellular antigen-binding component and intracellular-signaling components that have received the most attention and have been well described (van der Stegen et al., 2015; Ghorashian et al., 2015; Sadelain et al., 2013; Gill and June 2015; Jackson et al., 2016).
As can be seen from Figure 6, the SVR model based on sequence encoding scheme 'ALL' surpasses all the other models, which means that this encoding scheme has better sensitivity values given any choice of specificity in contrast to other encoding schemes.
The test for the significance of the covariance between α i and ξ i in the MREM approach is not significant (likelihood ratio = 0.999, p-value = 0.317), and hence there is no indication for the choice of specificities to depend on the level of individual curves.
Another difference is that Dukic's method assumes independence between the choice of the specificities as represented by the ξ ij parameters and the level of the study specific ROC curve as determined by α i ; a not necessarily realistic assumption.
Although nested PCR is considered the method of choice in terms of specificity [ 9, 13, 14], some additional aspects should be considered.
Management of T. b. rhodesiense patients is far from being optimal, thus both choices of high specificity or sensitivity would be associated either to a risk of missing the diagnosis of late stage patients, or to the exposure of S1 patients to a highly toxic stage 2 drug, respectively.
Screening tests usually warrant the choice of high sensitivity over specificity.
For the choice of cut-off, sensitivity, specificity, positive and negative predictive value for predicting outcome was 90%, 86.5%, 79.4% and 93.7%.
Consequently, our choices reflect a moderate level of specificity, and our benchmark list includes 19 concepts rather than, for example, 6 or 60.
16– 17 All guidelines and recommendations express the need of increased attention, timely diagnosis and appropriate treatment choice, but differ in their level of specificity, scope and views on the mode of administration.
These choices could then alter the values of specificity in the system.
