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However, the extent to which the results of PC analysis reflect the true underlying genetic map of Europe is critically dependent upon the choice of populations analyzed.
This choice of populations ensured that in each case, only representatives from a single lineage were studied.
RB contributed to the design of the study, the choice of populations and collection of specimens, and the writing of the manuscript.
Although the commonly used "multipopulation" principal component analysis (PCA) has many attractive properties, it should be practiced with caution to avoid biases due to the choice of populations and varying sample sizes (Price et al. 2006; McVean 2009).
In a comprehensive review of the literature on policy instruments and interventions, Bemelmans-Videc, Rist, and Vedung formulate the 'least coercion rule' [ 51]: policy-makers choose the intervention that is least intrusive into individual choice of populations (as evidenced for obesity policy by, for instance, Allender et al. [ 52]).
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The information stored in gbest and pbest makes the choice of population for next iteration more informed.
We also show, through numerical examples and a case study, that the proposed design can result in significant improvements in efficiency compared to simple random sampling without replacement designs for a wide choice of population types.
This incremental behavior confirms a well established qualitative fact on the aging kinetics of endothelial cells, but it is necessary to stress that this result, for adult populations, shows proportionality with time (that is, the displayed experimental points show a common slope) This outcome is true irrespective of the choice of population included in the different research samples.
This choice of population size also allowed us to clearly differentiate between edge and center positions.
When the weekly average incidence was zero, the annual population was used since the choice of population was irrelevant.
Such a procedure would benefit from the fact that the order appears to be insensitive to the choice of population.
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