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These threats should be addressed using recognised approaches, including appropriate choice of comparators, detailed understanding of the change processes at work, careful specification of research questions, and the use of falsification tests and other methods for strengthening causal attribution.
Number of field locations; number of years and representativeness of the selected locations with regard to the intended market release (in all cases the entire EU); characterisation of individual locations; choice of comparators (controls); use of appropriate pesticide management in trials with HT GMPs; and relevance of estimated agronomic parameters.
The same holds true for the choice of comparators.
We are confident that we eliminated survival bias in our choice of comparators.
Objectives, study design, and choice of comparators were mostly well reported.
This is illustrated in identified differences in discounting, perspective, time horizons, choice of comparators and strength of underlying evidence.
Similar(48)
Qualitative extrapolation and quantitative modeling of data regarding study duration, patient population, choice of comparator, and type of outcomes.
In addition to the choice of comparator, a number of other pathway characteristics influenced the degree of cost saving.
Modeling is expected to be performed wherever possible and appropriate, e.g. for study duration, patient population, choice of comparator, and type of outcomes.
The choice of comparator is not limited to (branded or generic) pharmaceuticals but may also include non-pharmaceutical interventions (e.g. surgical procedures) (Section 2.2.5 GMTA).
The most difficult issues were the feasibility of including a co-primary measure of functional improvement and the choice of comparator agent for a trial of a broad spectrum agent (with antipsychotic and cognitive-enhancing effects).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com