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The phosphorylation status of β-catenin at key residues is critical to its choice of binding partner [19] [21], and the N- and C-termini, which act as Wnt transactivation domains [22] [23], also interact sterically with the central Armadillo repeats.
This qualitative evaluation categorized TFBRs as either shared or unshared in a particular pair of species; the choice of binding cutoff and effect of varying this cutoff is explored in Figure S1E.
For Locus 3, the model predictions did not agree with the experimental data regardless of the choice of binding intensities, unless an additional assumption on the locus structure was made, which received, however, further support (ref. to Discussion).
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The choice of bindings is in full accord with the soft hard acid base principle.
New resins under development are welcome in order to provide caregivers with additional options in the choice of K+-binding resins.
This streak of independence in Taft's opinions make it no surprise that he was one of Elbert Hubbard's admirers, and that must have influenced Taft's choice of the Roycroft binding style for this presentation to his colleague and friend Loveland Munson.
The reduced free energy between MB target duplexes and unbound MB, creates an environment where the energetic choice of target-specific binding is reduced by a single base mismatch [16].
The study also underscores the need for large-scale eQTLs mapping efforts that might provide experimental evidence for SNPs that alter the choice of transcription factor binding sites.
A good choice of terminology for binding is SNOMED CT [ 12], being the most comprehensive clinical terminology and comprising over 350,000 defined terms [ 13].
The training algorithm, described in detail in [ 87], partitions at each iteration the training set associated to an internal node into two groups according to a particular choice of a TF binding site motif and a threshold c; one determines a subset of genes associated to the left child and the other one a subset of genes associated to the right child as explained before.
Our results are validated by comparison with DFT calculations [29, 69], which allow us to establish unambiguously our choice of the tight-binding parameters for these systems.
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