Exact(1)
We did not detect partial homology with other rdhA that would suggest vcrA is a chimera resulting from a recent homologous recombination event.
Similar(59)
Treatment with EphB4/Fc chimera resulted in activation of PI3K, Src, and MAPK pathways.
As shown in Fig. 1b, a single dose of 2 nmol/mouse of the chimera resulted in the reduction of survivin mRNA in the xenograft tumour by ~40%.
As shown in Fig. 1a,e,e, the treatment of chimera resulted to a ~70% knockdown of both survivin mRNA and protein levels in EpCAM-positive HT29 cells but not in the EpCAM-negative control HEK293T cells.
Rac1CTCdc42 chimera resulted from the replacement of the region encoding the last carboxyl-terminal 14 residues of RAC1 by that of the last carboxyl-terminal 12 of CDC42.
The reciprocal Cdc42CTRac1 chimera resulted from the replacement of the region encoding the last carboxyl-terminal 12 residues of CDC42 by that of the last carboxyl-terminal 14 of RAC1.
HsRac1CTCaRac1 chimera resulted from the replacement of the region encoding the last carboxyl-terminal 12 residues of HsRAC1 by that of the last carboxyl-terminal 14 residues of CaRAC1.
A similar inhibitory phenotype was evident for the Y543F mutant, but BCR co-ligation with the Y556F chimera resulted in effects analogous to the WT.
Surprisingly, removal of phosphorylation sites from this chimera resulted in a receptor that is constitutively internalized, even in the absence of agonist.
Overexpression of the mChFP-Tmod2/Tmod1 chimera resulted in a 1.5-fold decrease in the number of neurites (2.2 ± 0.98 neurites/cell) compared to the number seen with GFP-Tmod1, 3.1 ± 1.22 neurites/cell.
A real-life example that illustrates the possibility that chimera research might disrupt a useful social practice is the attempt in 1998 by Stuart Newman (a professor of cell biology and anatomy) and Jeremy Rifkin (an anti-biotechnology activist) to patent a broad range of chimeras resulting from the mixing of human and nonhuman embryonic cells (Heathcotte and Robert 2006; Rabin 2006).
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