(This implies that with the same pyroGlu to proline mutation and with paddle chimera the effect of the pyroGlu to proline mutation would be less information that we don't know about).
Using bone marrow chimeras these effects were mechanistically mapped to non-haematopoetic cells suggesting that the effects are intrinsic to cardiac tissue.
The over-expression of the TM8 SRDX repressor chimera had macroscopic effects on both reproductive and vegetative structures.
To compare gain of invasiveness to gain of plasminogen activation, we tested the Pla-Epo chimeras for their effect on invasion into the ECV304 cell line.
A similar inhibitory phenotype was evident for the Y543F mutant, but BCR co-ligation with the Y556F chimera resulted in effects analogous to the WT.
Our experiments, performed with bone marrow chimeras, demonstrate an effect on MI healing with a ≈80% knockdown of Lp-PLA2, indicating this is a sufficient reduction to elicit positive effects.
The second is in a macrophage-derived cell line, J774, in which interleukin-10, which activates STAT3, leads to antiproliferation, and expression of an inducibly active STAT3-gyraseB chimera mimics the effects of interleukin-10 [ 49].
In particular, our findings that both chimeras had no effect in terms of mitochondrial sequestration of intracellularly released Ca2+ while they mimicked the effect of wild-type UCP2/3 on mitochondrial uptake of entering Ca2+ significantly differ from the previous results with UCP2/36G (Table 1).
Furthermore, the generation of SJL FCG bone marrow chimeras identified an effect of XY on CNS neurodegeneration, where having an XY CNS confers greater spinal cord and cerebellar pathology in SJL chimeric mice reconstituted with the same immune system, but differing in the sex Chr complement in the CNS [ 64].
Although all chimeric G-proteins were able to moderately improve OR signaling, the Gαs chimera had the strongest effect (Figure 4B).
