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It is unknown whether further expansion of the Dutch childhood vaccination program with other vaccines will be accepted and whom should be targeted in educational strategies.
After the introduction of a H. influenzae type b (Hib) vaccine in the childhood vaccination program in 1992, non-typeable H. influenzae (NTHi) have dominated H. influenzae morbidity in Sweden [ 2], but NTHi are less prone to cause severe infections than Hib in unvaccinated populations [ 3].
About 95% of infants and young children in the Netherlands are vaccinated under the universal childhood vaccination program [ 7].
For the UK, individuals, clinically at-risk (ages 18 64 years and 65+ years) are vaccinated and a universal childhood vaccination program for children of ages 2 17 years is being phased in as of 2013.
Subsequently, the vaccine was introduced into the childhood vaccination program as a 1-dose strategy in 2011 and a 2-dose strategy in 2013.
The 7-valent pneumococcal conjugate vaccine was introduced in the Danish childhood vaccination program in October 2007.
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In fact the only mucosal vaccine that has been widely used globally for infant and childhood vaccination programs is the oral polio vaccine (OPV) developed by Albert Sabin in the 1950s.
http://www.clinicaltrials.gov NCT00332566 Combined diphtheria-tetanus-whole cell pertussis (DTPw) vaccines remain the cornerstone of childhood vaccination programs in Latin America and many other parts of the world [ 1].
Childhood vaccination programs fail to be beneficial if vaccine efficacy falls to <25%, levels that have never been reported in younger or high-risk children (1 ).
As the vaccine is not yet introduced in childhood vaccination programs, the impact of this public health intervention relies in large part on the herd protection afforded by the vaccine.
In 1991, after the breakup of the Soviet Union, routine childhood vaccination programs were disrupted due to interruption of vaccine supplies to countries in Central Asia, the Caucasus, and the Baltic region.
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