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We undertook a literature search between January 1995 and February 2008 using MEDLINE, Pubmed, EMBASE, Cochrane central controlled trials register and Cochrane pregnancy and childbirth group trials register.
We also found that breast cancer incidence was lower and latency was shorter in the early childbirth group than in the late childbirth group.
We will search all reviews of the Cochrane Pregnancy and Childbirth group.
In the experimental groups, 32 rats had breast cancer (19 in the DMBA-treated nulliparous group, 3 in the DMBA-treated early childbirth group, and 10 in the DMBA-treated late childbirth group), resulting in a total of 54 tumors.
We assumed that all important obstetric studies published will be included in one of the reviews of the Cochrane Pregnancy and Childbirth group.
All reviews of the Cochrane Pregnancy and Childbirth group will be assessed for reviews on interventions that aimed to improve neonatal outcome.
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In this study, we divided SD rats into nulliparous, early and late childbirth groups.
The breast cancer incidences were 95.0%, 16.7%, and 58.8% in the experimental nulliparous, early childbirth, and late childbirth groups, respectively (all P < 0.05).
The AgNOR count per nucleus as well as percentages of positive tumors for C-erbB-2, PCNA, Ki-67, and MCM2 were significantly lower in the DMBA-treated early and late childbirth groups than in the DMBA-treated nulliparous group (all P < 0.01), but showed no significant differences between the early and late childbirth groups (Table 2).
In this study, we divided Sprague-Dawley (SD) rats into nulliparous, early childbirth, and late childbirth groups and induced breast cancer by DMBA to explore the effect of childbirth on breast Carcinogenesis.
AgNOR count and the expression of C-erbB-2, PCNA, Ki-67, and MCM2 were significantly higher in the experimental nulliparous group than in the experimental early or late childbirth groups (P < 0.05), but no significant differences were observed between the latter two groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com