Mr. Bush wants to cut funding for 2002, in per child terms, by 2percentt.
The child terms has both negative and positive regulation some of which include GO: 0002242 defense response to parasitic plant and GO: 0002213 defense response to insect.
Consider that the true function of a protein with a non-specific GO term can be a single specific GO term among many possible child terms.
One is the GO database, from which 217 human genes annotated with 'Chromatin modification' or its child terms (see above) were downloaded.
The probability of a GO term is the number of times that it or any of its child terms occur in a data set.
A list of 230 S. cerevisiae genes annotated with "chromatin modification" or its child terms was obtained from the Gene Ontology database [6].
Twenty significantly up-regulated GO functional terms were shared by 2,4DNT, 2,6DNT, 4ADNT and TNT, among which at least half were child terms of "metabolic process" and "cellular metabolic process".
"Amino acid metabolic process" and/or its child terms, "organic acid metabolic process" and "carboxylic acid metabolic process", were significantly down-regulated by 2,4DNT, 2,6DNT, 2ADNT and TNT.
GOstats [23] and elim [24] adopt a reverse strategy: child terms (i.e. leaves in the hierarchy) are tested first, then parent nodes are modified so as not to include the genes present in their enriched children.
Of all our candidate CM genes, 21 are annotated as "chromatin modification" or its child terms with the evidence code IEA (Inferred from Electronical Annotation) in the GO catalog when the annotations were initially downloaded.
Additional File 1 details the results for all child terms.
