Under normal situation, the localization pattern of AKT-S129D is chiefly nuclear, owing to its constitutive activity due to phospho mimicking, but upon inhibition of CK2 activity, the nuclear level of active AKT declines significantly, while increases in the cytoplasmic fraction, as it happens when PML is overexpressed.
The changing pattern during the 11-year period manifests that the increasing deaths associated with diabetes should chiefly be owed to cardiovascular diseases but have nothing to do with diabetes as the underlying cause, that is, other diabetic complications and diabetes without complications.
The vote in Illinois puzzles even the most experienced campaigners, owing chiefly to the uncertainty as to which way the women electors will vote.
Despite efforts to take part in the university's social life, the two semesters at Bonn were a failure, owing chiefly to acrimonious quarrels between his two leading classics professors, Otto Jahn and Friedrich Wilhelm Ritschl.
The chief obstacle in empiricists' minds to explaining causation in terms of counterfactuals was the obscurity of counterfactuals themselves, owing chiefly to their reference to unactualised possibilities.
There is an overall growing significant attention focused on the subject of entrepreneurship from the past few years owing chiefly to the findings and realization by economic analysts throughout the world that small firms contribute substantially to the greater economic development and vitality of any society or country at large.
Or it may be the way that young Japanese businessmen discuss it with the reverence usually reserved for MBA courses.Its success on Sunday is owed chiefly to two factors.
There is an inherent conservatism to the legal profession, owing to its commitment to working chiefly through existing institutions and to the fact that law itself is predominantly intended to satisfy expectations arising from inherited patterns of behaviour.
This was chiefly due to their uncertainty as to whether dyspnoea limited activity owing to the presence of other limiting conditions (eg, arthritis).
Even with the remarkable success in managing thrombotic events, the long-term use of heparins and coumarins is associated with a number of drawbacks which chiefly include unavoidable risk of bleeding, narrow therapeutic window, variable patient response and various other complications owing to their non-specific binding, food and drug interactions and immunologic reactions [ 6– 8].
