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MAIN OUTCOME MEASURES: The primary efficacy endpoint was the change from baseline in best-corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study ETDRSS) letters at week 52.
The primary efficacy endpoint was viraemia as measured by qRT-PCR in whole blood sampled daily over the entire two-week monitoring period.
The primary efficacy endpoint was the proportion of patients transfused.
The primary efficacy endpoint was the change from baseline to week 26 in MG-ADL total score measured by worst-rank ANCOVA.
The primary efficacy endpoint was >30% deterioration in triple timed up-and-go (3TUG) times during tapered drug withdrawal.
For the primary efficacy endpoint, an intention-to-treat analysis was undertaken on all patients with ≥1 efficacy assessment.
As an exploratory analysis, the primary efficacy endpoint was reassessed using active control as comparator.
The primary efficacy endpoint was non-inferiority of HP relative to G + T for success at achieving hemostasis within 6 minutes.
The composite primary efficacy endpoint was cardiac/unexplained death, new Q-wave myocardial infarction, or detection to presentation time >2 h.
The primary efficacy endpoint (stroke or non-central nervous system embolism) was examined by quartiles of cTTR and by cTTR as a continuous function.
Change in viraemia by PCR was the main efficacy endpoint and sero-reversion the secondary one.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com