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chicken anemia virus.
Apoptin, a small protein derived from chicken anemia virus (CAV) was the first one discovered.
Apoptin is a small (14 kDa) apoptosis-inducing protein encoded by VP3 gene of chicken anemia virus (CAV) which can induce apoptosis in various human tumors or transformed cells, but not in primary non-transformed cells (Danen-Van Oorschot et al. 1997; Los et al. 2009; Maddika et al. 2006).
Chicken anemia virus (CAV), is a non-enveloped virus and the causative agent of chicken anemia disease.
We compare our results with the only other better-studied member of Circoviridae, chicken anemia virus.
derived from chicken anemia virus (CAV) (Noteborn et al., [ 4]) and possess tumor-specific apoptosis-inducing activity.
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Non-respiratory avian pathogens, including chicken infectious anemia virus, fowl adenovirus, avian reovirus and infectious bursal disease virus, did not produce DNA products.
This virus belongs to the genus Gyrovirus of the Circoviridae family and causes a severe immunosuppressive syndrome and anemia in chickens [ 2].
The disease results in aplastic anemia, lymph organ atrophy and immunosuppression in chickens [ 1- 3].
For >30 years, this virus, which was responsible for severe anemia and increased death rates in young chickens, was considered to have an extremely low genetic diversity and to be specific to this animal host.
However, like related animal viruses, CAV infects a large range of cell types and causes a variety of pathologies (including bone marrow aplasia leading to aplastic anemia, hemorrhage, and lymphoid depletion) and increased death in young chicken (11 ).
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