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The present study was designed to establish a chick model for the mechanisms of SM on neurobehavioral teratogenicity, free of confounds related to mammalian maternal effects.
The present study was designed to evaluate the suitability of a chick model for phthalate DEHP teratogenicity and neurobehavioral teratogenicity, a model which is simple and devoid of potential confounding factors such as maternal toxicity, maternal-fetal unit and maternal-neonatal interactions; major findings were confirmed in the DBP study.
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This report presents a dietary chick model of severe hyperhomocysteinemia as a superior alternative to the CBS-knockout mouse [ 7] for study of connective tissue abnormalities.
IGF has been shown to be associated with myopia in a chick model.
To assess the chick as a model for the investigation of Plxdc2 function we first confirmed similar expression to that previously demonstrated in the mouse during nervous system development [9].
The team used in ovo chick embryos, an established model for assessing teratogenicity, to evaluate the effects of exposure to inorganic arsenic.
We also conclude that the hCySH-supplemented chick is a promising model for study of the connective tissue abnormalities associated with homocystinuria and an important alternative model to the CBS knock-out mouse.
This fact probably explains the difference in turnover rates between the chick and roach fish diets and the lack of convergence for the exponential model for the chick diet, whose initial isotopic difference was less marked (Table 1A; Fig. 2A).
Although chick embryo never been used before for creating ischemia, efforts were made to develop chick embryo based flow-manipulation model for shear stress associated research [8] [10].
Chick chorioallantoic membrane as a model for simulating human true vocal folds.
The chick, thus, provides a suitable model for the rapid evaluation of SM behavioral teratogenicity and elucidation of the mechanisms underlying behavioral anomalies.
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