The possible reason might be that several consecutive therapy lines with different chemotherapy classes are used.
Side-effects induced by these new treatments usually differ from those observed with chemotherapy, are class-specific, and some remain poorly documented.
There was no relationship between acute GVHD and the number of cycles of chemotherapy or classes of agents used in the 6 months prior to HSCT We utilized cause-specific hazard ratios (CSHR) to assess risk factors for acute GVHD grade 2 or higher, along with the competing risk of all-cause mortality within 100 days of HSCT.
When the cohort was stratified according to systemic therapy, NPI+ was found to predict good vs adverse outcome for all of the biological classes in both hormone therapy-treated patients and chemotherapy-treated patients with the exception of chemotherapy benefit in class 5 (Basal p53 normal) in which few deaths were observed in the group as a whole.
Our data suggest that chemotherapy of MHC class I-deficient tumours with 5AC combined with immunotherapy is an attractive setting in the treatment of MHC class I-deficient tumours.
Taken together, our data document that chemotherapy of MHC class I-deficient tumours with DNMTi combined with non-specific immunotherapy is a promising therapeutic setting against MHC class I-deficient tumours, although both positive and detrimental effects of DNMTis have to be considered and the immunotherapeutic settings have to be optimised.
In a stepwise multivariate Cox model considering RPA class, chemotherapy and acute CNS toxicities, only RPA class and acute NT remained statistically associated with the overall survival (HR=1.43; 95% CI=1.2 1.7; P<0.0001) after adjusting for the RPA classes (Table 5).
Ann's blog contains an honest, no-nonsense approach to her daily chemotherapy appointments, spin classes (yes, that's right she exercises), MRI scans, and parenting.
Anti-mitotic drugs that target microtubules (Taxanes, Vinca Alkaloids) are mainstays of current chemotherapy, and new classes of anti-mitotics that specifically interfere with the assembly of bipolar mitotic spindles by inhibiting various mitotic kinases or kinesin motor proteins are under development [4].
