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In regard to chemotherapy, analysis focused on the time of chemotherapy in respect to surgery (induction vs. postoperative chemotherapy).
Given possible data pointing toward differing efficacy by line of chemotherapy, analysis was stratified into second-line trials and trials investigating third-line (or later) setting.
Considering that patients in ANITA received cisplatin-based chemotherapy, analysis of our data showed that the cisplatin-based chemotherapy group had improved survival (median 41 months, 5-year OS rate 40.2%), which was comparable to the outcome of the ANITA trial.
However, multivariate analyses adjusting for the number of metastases, prior chemotherapy (analysis of progression-free survival) and the disease-free interval (analysis of overall survival) favored adjuvant chemotherapy with regard to progression-free survival (HR 1.39; 95% CI 1.04 1.85) and overall survival (HR 1.39; 95% CI 1.00 1.93).
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Prior to commencing chemotherapy sperm analysis, hormone (LH, FSH, testosterone) analysis, audiometry and pulmonary function tests were performed.
As DTC status identifies a high risk group after completion of chemotherapy, DTC analysis during follow-up may open opportunities for introducing additional treatment.
To establish if expression of SNIP/p140Cap mRNA is predictive of response to adjuvant chemotherapy, Kaplan Meier analysis was performed on those cases only where chemotherapy was administered.
To control for the effects of systemic chemotherapy, subset analysis was performed comparing outcomes of the three predominant RT techniques for stage III/IV patients in the setting of concurrent chemotherapy.
Based on recently published data for an adjuvant chemotherapy cost analysis (Michel et al, 1999), the expected cost for adjuvant chemotherapy would be $5485 per patient and the expected cost per life saved at 5 years would be $30 472.
Although the development of drug resistance occurs as an adaptive response to chemotherapy, our analysis of tumours from chemotherapy-naive patients suggests that individual tumours may, before treatment, have inherent differences in drug sensitivity.
Furthermore, although CD30 expression did not appear to affect the response to GELOX or EPOCH chemotherapy, survival analysis indicated that CD30-positive patients had a significantly inferior OS and PFS.
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