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Among the 211 associated loci, we identified 37 promising candidate genes (7 with significant cis-eQTLs12) with functional annotations related to the pathways of flavor chemicals (Table 1).
Here we summarized the compounds or natural product extracts with explicit anti-aging activity, including 185 compounds from natural products (Table 1), 55 complex or extracts from natural products (Table 2), 62 from clinical drugs (of which more than 50% are also from natural products or natural products analogues, Table 3), 35 from synthesized chemicals (Table 4).
The NRG correctly grouped 6 out of the 8 replicate chemicals (Table 1).
Compared to other strains of Shewanella, obligate marine S. halifaxensis and S. sediminis were predicted to have more and unique CDSs associated with adaptation to sea salts and toxic chemicals (Table 3).
Among the 58 optimized genes, 93% genes exhibited toxicant-specific gene expression alterations, that is, 32 genes responded specifically to TNT, 22 to RDX, and only 4 to both chemicals (Table S3).
Exposure of sandwich cultured hepatocytes to varying concentrations of either LCA or PCN for 48 hours resulted in a dose-dependent increase in the total number of genes activated, with similar total numbers of genes affected by both chemicals (Table 2).
Similar(40)
A chemical table file consists of two main parts.
Fig. 4 Three standardized chemical identification formats from left to right: Smiles, InChIs and chemical table.
Some chemical table file-derived formats allow an additional property block.
Another identification format that is relevant in this work, are chemical table files [18].
In KEGG this is done simply by joining the separate chemical table files of each molecule that participates in the reaction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com