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Columns of the table include Experiment type; Mutant information (incorporating both Mutant type and Allele information, if any); Strain background; Phenotype (observable and qualifier); Chemical (any chemicals relevant to the phenotype); Details (including the properties 'Details', 'Condition', and 'Reporter'), and Reference.
Rational metabolic engineering methods are increasingly employed in designing the commercially viable processes for the production of chemicals relevant to pharmaceutical, biotechnology, and food and beverage industries.
The incorporation of 14C-leucine into rabbit lung slices was monitored in the absence and presence of selected drugs and chemicals relevant to the perturbation of lung function and the development of lung disease.
Even if we assume that the mixture assessment concept of independent action is applicable to the multitude of chemicals relevant to human exposures, certain risks may arise from small effects associated with single chemicals which might cumulate according to stochastic principles.
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'Chemical' refers to any chemical relevant to the phenotype, and is most often used to record a drug or chemical stress to which the mutant may display resistance or sensitivity, but may also be used to record alternative carbon sources, required amino acids, or other substances involved in assaying the phenotype.
Using carcinogenicity as an end point, we present approaches for developing predictive tools for toxicologic evaluation of chemicals and chemical mixtures relevant to environmental contamination.
The $5 million California Breast Cancer Research Program initiative "Making Chemicals Testing Relevant to Breast Cancer" is a model for stimulating research in this field, and the National Institute of Enironmental Health Sciences NIEHS Breast Cancerer and the Environment Research Program is contributing knowledge about puberty as a critical window of development and susceptibility.
In a milestone for studying a class of chemical reactions relevant to novel solar cells and memory storage devices, scientists used LCLS to watch "molecular breathing" – waves of subtle in-and-out atomic motions – in real time and unprecedented detail.
Scaffolds are used to aggregate data and detect patterns for several reasons: (1) Scaffolds relate analog chemical series, relevant to medicinal chemistry and lead optimization.
First, the KEGG database (a database of small molecules, biopolymers, and other chemical substances relevant to biological systems) was used to analyse the relationship between MTLD entries and biological processes.
We therefore screened C. elegans for chemotactic responses to chemical vapours relevant to a range of explosives and obtained several hits.
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