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In this case, chemicals able to bind this conformation are expected to achieve full inhibitory potential.
Knowledge of an MIE can be used to design high-throughput in vitro assays to screen for chemicals able to trigger that MIE.
Despite these limitations, initial analyses of data from ToxCast Phase 1 have identified those chemicals able to induce oxidative stress as evidenced by Nrf2 activity (Martin et al. 2010).
A review of the literature identified several hundred references reporting more than 50 chemicals able to cause cancer after perinatal exposure in animals [Supplementary Table S1 (http://ehp.niehs.nih.gov/docs/2005/7667/supp.pdf)].
This model organism offers simple readouts, such as the common respiratory growth defect observed in yeast models of mitochondrial disease, to enable large-scale screens for genetic suppressors (Box 4) and chemicals able to rescue mitochondrial dysfunction.
With the aim of discussing new research findings about chemicals able to interfere with the endocrine system, so-called endocrine disruptors, an international workshop was held in Prague, Czech Republic, 10 12 May 2005.
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BPA has been acknowledged to be an estrogenic chemical able to interact with human estrogen receptors (ER) (Dodds and Lawson 1938; Krishnan et al. 1993; Olea et al. 1996), and many lines of evidence have revealed that BPA, at even low doses, acts as an endocrine disruptor (Gupta 2000; Nagel et al. 1997; vom Saal et al. 1998; Welshons et al. 2003).
Combinations of endocrine disrupting chemicals are able to produce significant effects, even when each chemical is present at low doses that individually do not induce observable effects[23].
"For the washing process to happen the tumbling action needs to occur with the water and chemicals being able to move freely around the clothes".
Shouldn't steel tanks containing dangerous chemicals be able to withstand the consequences of winter weather?
All chosen chemicals were able to bind to and activate the estrogen receptor alpha.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com