The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines.
Overall, our development of this RASSL form of hFFA2 represents a novel, more rational, approach to chemically engineering ligand selectivity at a GPCR based on pharmacological differences between species.
In this respect, a rational design of effective chemically modified siRNA must consider as a general principle that the two strands of siRNA function differently and as practical hint that the nucleotides are different according to positions and nature.
A rational design of effective chemically modified siRNAs must consider the 3′ and 5′ termini of siRNAs as critical determinants for the silencing activity because these regions interact with the binding domains of hAgo 2, that is, the signature component of the RNAi machinery.
We argue here that it may be possible to chemically encode distinct signaling profiles into ligands by rational ligand design.
The three broke away from the standard practice of developing new drugs by chemically modifying naturally available compounds; instead, they adopted a more rational approach, based on understanding of the basic and biochemical processes of a disease.
The chemical moieties identified in this large-scale screen provide chemically defined conditions for the culture and manipulation of hESC-CMs, as well as a framework for the rational design of superior biomaterials.
The methodology will contribute to the further production of chemically and structurally divergent, unnatural natural products, as well as the rational design of novel biocatalysts with unprecedented catalytic functions.
To optimize chemically defined (CD) media efficiently and effectively for the biopharmaceutical industry, a two-step rational strategy was applied to optimize four antibody producing Chinese hamster ovary (CHO) cell lines.
The theoretical analysis presented in this paper suggests a rational way how to use enthalpy data in the mathematical model of a complex chemically reacting system.
