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This acts as a transcription factor: a chemical switch that turns on production of a variety of other proteins, one of which is EPO.
As a result, light-activated antibiotics would probably be limited to easily accessible infections on the skin (in wounds, for instance) or in the mouth, ears or nose.At least for now, that is, for Dr Feringa is working on flipping his chemical switch using sources of energy found inside the body, such as heat or certain energy-rich enzymes.
This works as a chemical switch which represses the fatal gene.
Surface functionalization of alumina powders with a responsive surfactant (BCS) leads to particles that react to a chemical switch.
High-purity micro-rod β-Na0.33V2O5 particles 25 μm in width and 310 μm in length are prepared by the chemical switch method.
This enabled the design and development of reusable chemical switch based dual optoelectronic sensor, for monitoring of traces of nitrite in environmental and food samples.
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Some of those environmental influences may affect chemical switches turning genes on and off, acting as an "epigenetic" layer of control sitting above the genome, and, he writes, in certain cases etching themselves as "permanent, heritable marks" that may be passed on to future generations.
The time elapse and concentration of sulphamic acid required for chemical switching was also established.
Stress reduces the sensitivity of the receptors (in effect chemical switches) which are supposed to control the level of inflammation in the body.
The discovery of this family of soluble receptors and the rich insight already gained from structural studies of their complexes with different isoforms of ABA, PP2C, and the synthetic agonist pyrabactin lay the foundation towards rational design of chemical switches that can bolster drought hardiness in plants.
Furthermore, to be applicable in biochemical and biomedical contexts, the chemical switching mechanism should be nontoxic to cells and orthogonal to most biological triggers.
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