J.M.S. performed the chemical screen.
A chemical screen probing the relationship between mitochondrial content and cell size.
A chemical screen to identify host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.
In 2000, the first chemical screen using living zebrafish in a multi-well plate was reported.
Wang, P. et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
We initially screened over 100,000 compounds in a high-throughput chemical screen to find a molecule that was effective in killing leukemia cells.
Using NANOPS in a cell-based chemical screen, we now identify macrotetrolides, known ionophoric antibiotics, as submicromolar disruptors of Ras nanoclustering and MAPK signaling.
First, we performed a time course experiment to optimize the time window for the chemical screen and determined that cell apoptosis significantly increases from day 25 to day 29 of the differentiation protocol (Supplementary Fig. 6a).
Shahar OD, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, et al. A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair.
Having access to the disease-relevant cells presenting a clear disease phenotype, we carried out a high-content chemical screen to identify drug candidates that can rescue the increased cell death in GLIS3−/− cells.
We then performed a chemical screen and identified several small molecules that increase or reduce cardiomyocyte proliferation during heart development.
