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These results suggest that unless a CdLS mutation directly affects the conformation or chemical function of a catalytic residue, the catalytic activity of a CdLS HDAC8 mutant may be partially or fully rescued by a small molecule activator such as TM251.
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In the literature, it has been concluded that properly interconnected and continuous pores with their spatial distribution could contribute to perform diverse mechanical, biological and chemical functions of a scaffold.
Thus, if used in conjunction with cleverly engineered cell lines targeting receptor cytoskeletal linkages, probing the kinetics of receptor cytoskeletal unbinding with ultrasensitve force techniques can provide unique physical insight into the interactions involved in the chemical functions of a molecular adhesion complex.
An improved understanding of the dual mechanical and chemical function of bone, however, has permitted a more integrated biological view.
The permeation of THMs and water molecules across the functionalized graphene was dependent on the chemical function of the pores, the size of pores, and the pressure.
This I conceive to be the chemical function of humor; to change the character of our thought.
Further, modeling of UbiA was able to connect the decreases in enzyme activity to specific chemical functions of mutated residues, i.e. activation of a phenolate intermediate by D191.
Tag technology for RNA imaging in a living cell has been developed based on the unique chemical functions of exciton-controlled hybridization-sensitive oligonucleotide (ECHO) probes.
The resulting material had an increased solubility in organic media due to the chemical functions of the inorganic nanoparticles.
The special biological and chemical functions of chlorophylls are determined by their molecular structures, containing highly delocalized conjugated molecular orbitals (Figs. 1 and 2).
The variability in mobility, as demonstrated by Kd and Kf values due to environmental factors such as pH, ionic strength, and organic strength as well as the multiple chemical functions of the molecule are large.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com