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These ligands all share a common adenine ribonucleotide moiety, suggesting that many different domain superfamilies have converged to bind this chemical framework.
Overall, our work provides a chemical framework for a novel anti-miR therapeutic approach using γPNAs that should facilitate rational design of agents to potently inhibit oncogenic microRNAs.
The server provides support to the web application mostly in the form of API to access the precomputed background hierarchy as well as the functionality of the chemical framework.
In this work we implement a group contribution approach of the Statistical Associating Fluid Theory, named SAFT-γ to describe the molecular structure of each fatty ester and to evaluate the influence of its chemical framework in the behavior of biodiesel as fuel by predicting the more relevant thermophysical properties.
Proponents suggest that the use of the same chemical framework is an indicator that the two may be related.
The data further define a chemical framework for competition with pregnenolone sulphate at TRPM3 and expand knowledge of steroid interactions with TRPM3, suggesting direct steroid binding and pregnenolone sulphate-independent inhibition by progesterone.
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Towards developing more general and robust simulation tools applicable to a broad range of wastewater engineering problems, this paper evaluates a plant-wide model built with sub-models from the Benchmark Simulation Model No. 2-P (BSM2-P) with an improved/expanded physico-chemical framework (PCF).
However, physico-chemical framework of proteomes is relatively independent against GC pressure through a frequency complementation of GC-dependent amino acid pairs with similar physico-chemical property.
Indeed, it is worth exploring the biological significance of a stable physico-chemical framework of amino acids by the complementation of GC-dependent amino acids.
The physico-chemical framework of the complete proteomes withstood GC pressure by frequency complementation of GC-dependent amino acid pairs with similar physico-chemical properties.
One, is the relatively stable physico-chemical framework in the proteomes the material basis of species in response to the pressure for survival?
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CEO of Professional Science Editing for Scientists @ prosciediting.com