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Within the framework of the proposed approach each chemical bound is replaced by a narrow tube in which the electron moves and from which he cannot get away.
This suggests that, for 3-D similarity methods to provide biologically meaningful results, the conformer generation program employed should be able to routinely reproduce known "bioactive" conformers (e.g., an experimentally-derived ligand conformation of a chemical bound in a protein crystal structure binding pocket).
This paper is an attempt to delineate a methodological approach for the construction of mathematical models of gene expression regulation from the principles of chemical kinetics and chemical bound.
Crucially, this revealed that each chemical bound in a specific manner with different stereochemistry by hydrogen bonding to different residues located within the antibody binding site.
Documentation of human exposure and biologically effective dose (i.e., chemical bound to DNA) has been achieved for a wide variety of chemical carcinogens, including polycyclic aromatic hydrocarbons (PAHs), aromatic amines, heterocyclic amines, aflatoxins, nitrosamines, cancer chemotherapeutic agents, styrene, and malondialdehyde.
The model consists of coupled reaction-diffusion equations to describe the evolution within the tissue of the concentrations of three chemical species: a (concentration of free chemical), b (binding protein) and their complex, c (chemical bound to binding protein).
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Lloyd's List International, the shipping newspaper, said the vessel had been suspected of carry chemicals bound for Iraq.
Chemicals bound to a surface would be much more likely to meet and combine into the more complicated molecules typical of life, he believes.
A shipment of chemicals bound for Iran was returned to India after a timely discovery of the deal by American intelligence and a diplomatic offensive by the State Department.
Twenty percent of the blood is filtered through the holes in the capillary walls; molecules smaller than 60,000 molecular weight end up in the filtrate, while red blood cells, large proteins, and chemicals bound to plasma proteins are not filtered.
The team used a technique called gas chromatography to separate the chemicals bound up in the ancient samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com