This work emphasizes the importance of transcription and translation for the maintenance of the spindle assembly checkpoint, suggesting the existence of a mechanism dependent on cyclin B1 gene regulation during mitosis.
Dr Hartwell also discovered the existence of "checkpoints" in the cycle.
These previous data point to the existence of checkpoints that limit self-renewal of stem cells with abnormally increased Wnt activity.
Corinne Geller, a spokeswoman for the Virginia State Police, said that two years ago, PhantomAlert broadcast the existence of sobriety checkpoints in a general area, but without real-time location information.
The existence of these checkpoints, and harassment at border points, hinder the normal course of transactions and, in particular, the cross-border transport of goods.
Surprisingly, their overexpression in transgenic plants led only to a moderate increase in seed iron content, suggesting the existence of control checkpoints for iron loading and storage in seeds.
The existence of various checkpoints in apoptosis reveals a complex balance between cell survival and cell death in cells.
For example, previous work suggested the existence of a checkpoint that monitors septin assembly and induces a Swe1-dependent G2/M delay in response to defects in septin assembly [63], [64].
Our data also lead us to question previous assumptions concerning the existence of a checkpoint for preventing cells with an incompletely replicated and/or segregated genome from entering mitosis and becoming aneuploid.
Surprisingly, after the failure of cytokinesis in RP-pck2Δ cells, the ring reassembled in a fraction of cells, similar to observations made in wild-type protoplasts suggesting the existence of a checkpoint-like control monitoring completion of cytokinesis (Mishra et al., 2012).
