However, merotelic attachments are not detected by the spindle assembly checkpoint (reviewed in [1]), and therefore this seems unlikely to be the reason for the mitotic delay.
Then, as the problem-solving evolves, work with these team members consistently at key checkpoints to review the latest information and get their thoughts.
Companies that wish to embark on a smart manufacturing strategy should build in checkpoints to review and adapt their plans.
This phenotype could also be explained by the observed role of MAST at the microtubule-kinetochore interface, which would have direct implications in the control of cell cycle progression by the spindle-assembly checkpoint (for reviews see ref. 31).
Cuzzubbo, S. et al. Neurological adverse events associated with immune checkpoint inhibitors: review of the literature.
Eukaryotic cells have to deal also with the natural ends of linear chromosomes, which are structurally similar to DSB ends but must be protected from fusion, degradation and recognition by the checkpoint machinery (reviewed in [5] [7]).
Therefore, recombination must be tightly controlled through multiple mechanisms, such as those listed above, and coordinated with the cell-cycle checkpoint response (reviewed in Labib and De Piccoli 2011).
In vegetative cells, DDK has an essential function in the initiation of DNA replication as well as DNA repair and checkpoint activities (reviewed by Duncker and Brown, 2003; Kim et al., 2003; Labib, 2010; Sclafani, 2000).
To prevent precocious sister chromatid separation, the APC/C is inhibited by the spindle assembly checkpoint (SAC) (reviewed in Jia et al. 2013; Musacchio 2011), which is only silenced when all kinetochores achieve bipolar attachment to spindle poles.
A16 Court Reviews Checkpoints The Supreme Court justices heard arguments on the merits of "informational checkpoints" designed to find not wrongdoers but witnesses to a crime.
