Sentence examples for checkpoints induced from inspiring English sources

The experiments demonstrated above indicated a potentially important action of nicotine in perturbing the activation of G1/S checkpoints induced by γ-irradiation or BP treatment.

Moreover, UCN-01 may abrogate checkpoints induced by genotoxic stress due to inhibition of Chk-1 kinase.

As expected, increased levels of Wip1 abrogated G2/M and intra-S phase checkpoints, while decreased levels of Wip1 enhanced G2/M and intra-S phase checkpoints induced by both UV and IR treatment of cells [ 10].

To determine if other S-phase checkpoints induce a transcriptional response, we followed the expression of cdc22, an MBF-dependent transcript encoding ribonucleotide reductase.

Losing the ability to control cell cycle checkpoints induces abnormal genetic instability.

Loss of the ability to control cell cycle checkpoints induces abnormal genetic instability.

If DNA damage is irreparable or cannot be repaired in time, DNA damage checkpoints induce cell death or senescence, a state of permanent cell cycle arrest [21,22].

Exclusion of TSPs from the nucleus prevents them from activating cell cycle checkpoints, inducing cell cycle arrest, and initiating apoptosis resulting in unrestricted tumor cell propagation.

In mammalian cells, Msh2 plays a suppressive role in TNE reaction by either precluding the oligonucleotide annealing to the target gene or by maintenance of a cell cycle checkpoint induced by the MSSO itself.

However, neither checkpoint induced G1/S transcription in G2 prior to passage through mitosis and entry into the subsequent S phase.

It is conceivable that different mechanisms for the activation of cyclins and suppression of Chk2 activity are involved in nicotine-mediated growth promotion and perturbation of G1/S checkpoint induced by DNA damage (such as γ-irradiation and BP treatment).