Sentence examples for checkpoints and regulate from inspiring English sources
The effector proteins Cdc25, p53, and E2F1 function to activate cell cycle checkpoints and regulate the transcription of genes whose products are important in the end result of the DDR, whether it be DNA repair, apoptosis, or senescence.
It has been shown that it is a component of the mitotic spindle checkpoint and regulates the separation of sister chromatids through its downstream molecules.
The MRN complex plays a crucial role as a sensor of DSBs, in activating the signal transduction cascades that lead to cell cycle checkpoints and in regulating the DNA repair pathway selection.
These findings are consistent with the notion that E-cadherin anchors Apc2 in parallel with other factor(s) that function in anchoring the centrosome and regulate the checkpoint.
The function of AurC is ambiguous owing to the paucity of studies; however, it may serve as a potential chromosomal passenger protein as AurB and regulate spindle checkpoint.
Since KT-NB treatment induces cell cycle arrest during mitosis, we analyzed whether KT-NB cause cause mitotic spindle defects and regulate important mitotic checkpoints.
Progression of the cell cycle past these checkpoints is closely monitored and regulated by a cell cycle control system [ 66].
Such a mode of ERSU pathway regulation of ER inheritance is rather unusual when compared to cell cycle checkpoints that regulate DNA replication and transmission (Vleugel et al., 2012; Hayashi and Karlseder, 2013).
We show that BPA exposure induces aberrant expression of multiple checkpoints that regulate cell survival, proliferation and apoptosis and that such changes can be effectively ameliorated.
Together, these findings suggest that gut is equipped with multiple T cell- and antigen-limiting checkpoints to regulate IgA antibody responses.
In this study we performed a series of experiments to determine how PAF affects DNA repair by examining important checkpoints that regulate DNA repair and cell cycle progression.
