Sentence examples for checkpoint threshold from inspiring English sources
If this were the case, one would expect the population average transcriptome to change at some background pace until the checkpoint threshold is reached, then the cells quickly transition to a new state.
The amounts of geminin, aphidicolin and etoposide (Sigma) were titrated for each extract due to the different checkpoint activation thresholds of each batch.
It has been reported that the G2/M checkpoint has a threshold in the number of DSBs to determine the cell-cycle progression or arrest [ 29].
When telomere length falls under a certain threshold, the checkpoint response is triggered.
A similar threshold basis for checkpoint activation has been documented for other cell cycle checkpoints, notably the DNA replication checkpoint in which activation requires a certain quantity of single-stranded DNA (Branzei and Foiani, 2005).
Since we set the threshold at the G1/S checkpoint to be smaller than that at other checkpoints, G1 arrested cells accumulated in the population more than other arrested cells.
Although the threshold at the G2/M checkpoint was set to half of that at the S/G2 checkpoint, the number of G2 arrested cells was more than twice the number of S arrested cells.
However, different thresholds exist for checkpoint activation in G1 and G2/M as two DSBs (one HOcs) were sufficient for Rad53 activation in G2/M but not in G1 (two HOcs; Supplementary Figure 2A).
In addition, the G2/M checkpoint seems to have a defined threshold of 10 to 20 DSBs [ 37, 38].
When the cell size reaches the threshold, about 1.5 (size checkpoint, S2 in Figure 2(f)), MPF switches to the upper branch (arrow (3)).
It is now recognized, however, that some carcinogenic events—such as mutation, homeostasis, DNA repair, and checkpoint control— may in fact have thresholds.
