Sentence examples for checkpoint results from inspiring English sources

Rather, a combination of an overall asymmetrical DNA distribution and circumvention of the spindle assembly checkpoint results in a near-random reshuffling of the chromosome complement.

Contrary, previous reports showed that the identical escape of G2/M checkpoint results in the mitotic catastrophe cell death [24] [27].

Deletion of the checkpoint kinase Chk2 with defects in the G2/M checkpoint results in tumor predisposition, indicating that the G2/M transition is important for tumor suppression.

Failure of the spindle assembly checkpoint results in gain and loss of chromosomes, or aneuploidy, a condition associated with malignancy and birth defects.

On the basis of checkpoint results and previously validated data, we further categorized the SHV G238S mutation as SHV-2-like and the double SHV G238A + SHV E240K mutation as SHV-18 (5 ).

The previous study, however, reported that loss-of-function of the Aurora B-dependent "abscission checkpoint" results in cleavage furrow regression rather than in premature resolution of chromosome bridges.

These observations may be indicative of the activation of a chromosome or spindle checkpoint resulting from the effects of stress in Mnn1 null embryos.

Inhibition of topo IIα activity leads to initiation of the G2 decatenation checkpoint, resulting in G2 cell cycle arrest [23].

Many cancer cells exhibit a defective G1 checkpoint resulting in a dependence on the G2/M checkpoint during cell replication and, as such, inhibition of the G2/M checkpoint may be lethal in this context [20].

This DNA damage triggers the G2/M DNA damage checkpoint, resulting in DNA repair or apoptosis.

It could cause the formation of unusually stable microtubules and trigger the mitotic spindle checkpoint, resulting in apoptosis.