Sentence examples for checkpoint requirement from inspiring English sources

Phenotypic analysis of the strain revealed striking fitness recovery, indicating that accumulated mutations cooperate to bypass the MDF-1 checkpoint requirement and thus achieve long-term population survival.

The argument that a transcript is probably highly committed before release, with most of the spliceosome assembled, is a persuasive one with which we find ourselves in agreement, but this statement is not the same as a checkpoint requirement.

See also Figure 1 figure supplement 1. DOI: http://dx.doi.org/10.7554/eLife.00844.003 10.7554/eLiFigure44.004 Figure 1 figure supplement 1. Replication and checkpoint requirements during meiS.

Bipolar attachments are required for checkpoint silencing, consistent with the requirement that sister chromatids be segregated to opposite poles and each daughter cell receive a full complement of chromosomes.

As expected, complete loss of the Ndc80 complex results in the complete absence of a mitotic checkpoint underscoring the minimal requirement for Mad2 recruitment to establish and maintain a checkpoint arrest (Meraldi et al, 2004).

Interestingly, in an effort to elucidate the minimal structural requirements for checkpoint activation, Xenopus egg extracts were utilized to demonstrate that the length of single stranded DNA between the free ends of primed DNA, influenced the degree of Chk1 phosphorylation [39].

Overexpressed Bub3 evidently inhibited the homologous chromosome segregation, indicating that Bub3 is involved in monitoring the MI-AI transition, which is similar to a previous report firstly showing Xenopus Bub3 requirement for spindle checkpoint activation and for maintenance of the spindle checkpoint signal [50].

Compared with other industries that the anemic West Bank economy might look to develop, the information and communications technology sector has an advantage: it is much less affected by impediments to movement, like the barriers, checkpoints and permit requirements that Israel imposes on the territory in the name of security.

This indicates that CD8+ T cells need to override multiple checkpoints, including the requirements for activation signals for antigen presenting cells (APCs) and CD4+ T helper cells as well as bypassing regulatory T cell (Treg) suppression and molecular negative T cell regulators, in order to become pathogenic effectors [1], [2].

To determine whether decreasing PKA activity can bypass the requirement for the spindle checkpoint, we impaired the spindle checkpoint in spc24 -8 by deletion of the Mad2 checkpoint protein.

We also formulate constraints to represent the timing requirement of a checkpoint.