Sentence examples for checkpoint networks from inspiring English sources

Of the 82 possible checkpoint networks only two accurately predicted the chromosome missegregation rates for the two double mutants.

Cell culture experiments suggested that p53 and retinoblastoma (Rb) checkpoint networks respond to telomere dysfunction (Chin et al., 1999; Hara et al., 1991).

Chk2, Cyclin D1, and Cdc25C are functional components of the cell cycle checkpoint network [8].

Thus, both text and data mining contributed critical pieces to the spindle checkpoint network.

Understanding the topology of the checkpoint network that explains these results is the challenge for future studies.

Detailed models, including a much larger section of the spindle assembly checkpoint network acting in vivo, have also been developed by Ibrahim et al (2008a, 2008b, 2009).

An experimental estimate of this robustness has never been measured, though it is necessary for a better understanding of the wiring of the spindle assembly checkpoint network.

We expect a stronger role of molecular models in the time to come when more components of the spindle assembly checkpoint network will be known in greater detail.

The exact topology of the checkpoint network is unknown, so that the way in which signal amplification is achieved remains unclear.

Furthermore, in discussing this objection, it should be noted that checkpoint signals from a single unattached kinetochore are sufficient to maintain a mitotic arrest (Rieder et al, 1995), strongly suggesting that the checkpoint network is designed to achieve amplification.

The pioneering work of Doncic et al (2005) addressed possible molecular mechanisms for the spindle assembly checkpoint network using biophysical processes and measurements without the explicit identification of molecular components.