Sentence examples for checkpoint module from inspiring English sources

Finally, much poorer performance was achieved when a count based on only checkpoint module hits was used (Figure 4f).

Moreover, high expression of TTK (MPS1) in our mitotic checkpoint module has been reported to promote aneuploidy in breast cancer [ 43].

However, knockdown of the mitotic checkpoint module genes did not result in lowered Ki-67 intensity, suggesting that knockdown of the mitotic checkpoint genes does not hinder mitotic progression.

Using a combined modelling and experimental approach, we have characterised the degree of control over cell cycle period/growth rate for a complete checkpoint module within the S.cerevisiae cell cycle.

Thus, genes in the mitotic checkpoint module relate to a more aggressive disease phenotype within the otherwise low proliferating luminal A tumors, but also within the more highly proliferating luminal B tumors.

However, high activity of the mitotic checkpoint module correlated significantly to unfavorable prognosis in both luminal subgroups (luminal A P = 3*10-5, luminal B P = 0.01, log-rank tests).

This produced 1230 representative genes for checkpoint modules and 183 genes for gatekeeper modules for a 10% cutoff; and 2461 genes for checkpoint modules, 366 genes for gatekeeper modules for a 20% cutoff.

The p-value for methylation events in the gatekeeper and checkpoint modules was calculated in the same manner.

The largest identified hub was 'BP: complement activation, classic pathway' which, according to the Gene Ontology biological process definition, has cooperation with 567 checkpoint modules.

Thus there are two key factors in determining the extent of perturbation on the cooperation network: (1) the number of gene hits in gatekeeper modules and (2) the number of active links between gatekeeper modules and checkpoint modules (meaning simultaneous hits on gatekeeper modules and their linked checkpoint modules).

(1) Identification of highly represented genes in gatekeeper and checkpoint modules As the gene modules were created from relationships defined in ontologies, protein interaction networks, pathways and miRNA targets, individual genes will, in general, be present in multiple gene modules.