Nearly two decades ago, Wakeland and colleagues proposed a three-checkpoint model for the development of SLE based on their studies dissecting lupus genetic susceptibility using congenic mouse strains [ 5].
In [24], authors propose BlobCR, a checkpoint framework for High Performance Computing (HPC) applications on IaaS.
Checkpoint models propose that Mad1 and Bub1 act as stable kinetochore-bound scaffolds, to enhance recruitment of Mad2 and Mad3/BubR1, but this remains untested for Bub1.
Here we have tested critical aspects of the scaffolding model for Bub1 checkpoint function.
In summary, we have defined a precursory logical model for the G1/S checkpoint where ATR and ATM pathways activation by single and double DNA strand breaks is sufficient to determine three different cell fates: cell cycle arrest, apoptosis and senescence.
A suggested model for the hydroxyurea-induced checkpoint signaling and modulation by caffeine, 2-aminopurine, staurosporine, and sodium metavanadate is presented in Fig. 2.
10.7554/eLife.00844.015 Figure 7. Model for the pre-meiotic replication checkpoint in budding yeast.
In summary, we can say that the models of the two elementary resources for traffic and operation consumption can be considered strongly consumer-centric, but suffer form incompleteness and ambiguities (that we have pointed out) and the model for storage resource consumption is weakly consumer centric (checkpointing event is not observable), making the overall model weakly consumer centric.
A model for the exit from mitosis [23] describes the control of the checkpoint, however not considering BubR1 (Mad3 in yeast) nor MCC.
She insisted that she was the model for the "bicycle girl" in "The Longest Day"—the courier who was stopped at a German checkpoint while cycling to a rendezvous, a crucial message folded into her newspaper.
Our results are consistent with a model for heterochromatin silencing in which Swi6 assures coupling between heterochromatin transcription and RNA degradation by acting as an H3K9me2-specific checkpoint.
