Sentence examples for checkpoint maintenance from inspiring English sources

Members of Group F appear to have a role within recombination checkpoint maintenance.

Here, we show that Cenp-meta is required for prolonged mitotic checkpoint maintenance.

MK2 activity is critical for prolonged checkpoint maintenance through a process of posttranscriptional regulation of gene expression [ 47].

A dominant negative mutation of fission yeast smc6 arrested in response to UV irradiation similar to wild-type cells but displayed mitotic defects due to DNA aberrations, which is evident of a checkpoint maintenance defect (Harvey et al. 2004).

Together these data suggest that CDK1 regulates multiple events in human pluripotent stem cells ranging from regulation of mitosis, G2/M checkpoint maintenance, execution of apoptosis, maintenance of pluripotency and genomic stability.

The kinase activity of BubR1 is stimulated by the microtubule motor protein, CENP-E, and is required for checkpoint maintenance and signalling in metazoans (Abrieu et al, 2000; Mao et al, 2003, 2005; Weaver et al, 2003).

Chk1 and Chk2 are involved in various DNA-damage responses, including cell-cycle checkpoint, genome maintenance, DNA repair, and apoptosis [17].

Nevertheless, these DSBs are probably repaired eventually, perhaps due to increased activity of other repair pathways or prolonged arrest in cell cycle checkpoints allowing maintenance of fragile site stability.

CHEK2 is involved in various DNA damage responses, including cell-cycle checkpoints, genome maintenance, DNA repair and apoptosis [ 27].

BRCA plays an important role in DNA repair, activation of cell-cycle checkpoints, and maintenance of chromosome stability [ 6, 7].

The MRN complex, formed from dimers of the proteins encoded by MRE11A, RAD50, and NBN (MIMs 600814, 604040, and 602667), plays key roles in DNA double-strand break (DSB) repair, meiotic recombination, cell cycle checkpoints, and maintenance of telomeres [ 4].