Sentence examples for checkpoint integrity from inspiring English sources

To test the latter possibility, we monitored checkpoint integrity in csk1Δ cells exposed to DNA damage.

USP39 deubiquitinates aurora B kinase maintaining spindle assembly checkpoint integrity [ 103] while USP44 stabilizes Mad2/Cdc20 complex inhibiting premature activation of the APC/CCdh1 complex [ 104].

Chk1 maintains the DNA damage checkpoint integrity, however, if cells have sustained severe DNA damage and are no longer repairable, Chk1 may then play a role in apoptosis by interacting with BAK.

Such regulatory pathways trigger cell cycle arrest or apoptosis in response to intracellular challenges such as DNA damage, hypoxia and oncogene activation, with preservation of genomic stability [ 1]. pRb maintains checkpoint integrity through binding and blocking E2F transcription factors, a process reinforced by the G1 cyclin-dependent kinase inhibitor p16INK4a [ 2].

The third functional group was response to UV damage, and included the GO categories "response to UV", "DNA damage checkpoint", "DNA integrity checkpoint", and "double-strand break repair".

Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity for which gained the over name of securin.

Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity.

The G1/S checkpoint protects genomic integrity and prevents damaged cells from entering S-phase by inducing apoptosis [ 46- 48].

The overlapping genes are mostly associated with cell division, cell growth, kinase activity, translation, DNA integrity checkpoint and transcription regulation.

Under the conditions we used in this paper activation of p38 kinase was not observed after siRNA treatment, arguing against activation of the proposed centrosome integrity checkpoint.

The other four down-regulated gene sets were related with cell cycle and cell division, such as DNA integrity checkpoint and mitosis.