Sentence examples for checkpoint in the development from inspiring English sources
This indication that SIRPα may normally function as a checkpoint in the development of a specific subset of intestinal DCs contradicts previous findings in the spleen where pre-DCs from SIRPα mt mice were found to have a reduced ability to generate CD11b+ DC compared with WT pre-DCs 34.
The canonical Wnt signalling has been reported to regulate key checkpoints in the development of many tissues, and among them, also in lymphopoiesis [21].
An approach to support this type of projects would be to award, in an individual case-by-case basis and after peer-review, Phase Ib grants with clearly established checkpoints in the project development.
46 Together these studies suggest an important role for OX40 OX40L interactions in critical immunoregulatory checkpoints that are likely involved in the development of autoimmunity.
Although the molecular mechanisms of ISP biology are not well understood, our data indicate that an additional checkpoint is established at this point in the development to guarantee quality of the DP subpopulation.
A number of genes influence the level of these autoreactive B cells and whether they are eliminated or not during development at a central checkpoint in the bone marrow (BM) or at a later checkpoint in peripheral lymphoid tissues.
In this review, we critically assess recent trends in the development and applications of bispecific antibodies (bsAbs), antibody drug conjugates (ADCs), and immune checkpoint inhibitors (ICIs) as cancer therapeutics.
Expression of surface immunoglobulin (sIg) related receptors has been conserved in phylogenetically distinct species as a critical checkpoint in B cell development.
This particular stage represents a critical checkpoint in T cell development that is known as β-selection.
Furthermore, unlike T-cell autoreactivity, the development of B-cell autoreactivity towards citrullinated epitopes appears to be a significant checkpoint in the progression to RA.
