Sentence examples for checkpoint function have been from inspiring English sources

Mutants defective in this checkpoint function have been isolated in both budding and fission yeast by their sensitivity to DNA-damaging agents such as radiation or agents that block replication such as hydroxyurea (Nasim and Smith 1975; Enoch et al. 1992).

Moreover, DSB-induced checkpoint functions have been well documented in G1 haploids (see below) and are equally unlikely to enhance survival following DNA damage that induces DSBs in G1 haploids.

Loss of Brca1 function has been shown to lead to defective DNA repair, to defective G2-M cell-cycle checkpoints, to increased apoptosis, and to genomic instability.

In contrast, accurate G2/M checkpoint function had previously been reported in MCPH1-mutated patient-derived lymphoblastoid cell lines [4].

The Rod/Zw10/Zwilch proteins are required for checkpoint function and have been implicated in Golgi transport in interphase (Chan et al. 2000; Williams et al. 2003; Hirose et al. 2004; Varma et al. 2006).

Similar transcription and checkpoint functions have also been described for human BRCA1, permitting other interpretations of the brc-1 defects as well.

In terms of the mechanisms underlying this checkpoint function, CHFR has been shown to exclude Cyclin B1 from the nucleus, resulting in the arrest of the cell cycle at around the G2 phase [7].

In fact, centrosome has been found to play an important role in G2/M checkpoint function in that a growing number of G2/M checkpoint regulators have been found in the centrosome [ 75]. p53 functions are ultimately mediated by activation and repression of target genes.

10/20/02 - The files for Checkpoint 2 have been updated.

On the other hand, many caspase substrates that function in cell cycle checkpoints have been identified, and dysfunction of these proteins has been suggested to contribute to tumorigenesis [45] [47].

Checkpoint 1 grades have been posted.