Sentence examples for checkpoint expression from inspiring English sources

Local IFN-driven immune checkpoint expression can mediate feedback inhibition and adaptive immune resistance.

Similarly to EGFR mutations, a potential effect of ALK translocation on checkpoint expression cannot be excluded and additional studies are recommended in this particular NSCLC subpopulation.

Although the usage of a new scoring system could represent a potential limitation, such method allowed us to assess more properly the association of checkpoint expression with patient characteristics.

Although the association was not statistically significant and although we were not able to evaluate whether a different checkpoint expression impacted on efficacy of anti- ALK agents, median PD-L1 levels were 5 times higher in ALK positive when compared with triple negative patients.

The evidence that PD-L1 expression is a potential negative prognostic factor in several cancers further supports the hypothesis that the observed improvement in TTP was related to an indirect effect of the therapy on checkpoint expression (Zou and Chen, 2008).

Immune-modulatory and checkpoint gene expression is strongly correlated with elements of the polarized immune response signature.

When DNA replication is inhibited, activation of the Cds1-dependent replication checkpoint represses expression of the mei4 + gene (Ogino & Masai 2006).

In correlative preclinical studies, higher PD-1 (programmed death-1), a T-cell checkpoint ligand expression, was associated with greater trastuzumab benefit.

Among the mitotic checkpoint regulators, expression of KNTC1 was significantly reduced in advanced group while MAD2L1 showed a non-significant decrease.

Under DNA replication stress, activation of the Cds1-dependent DNA replication checkpoint suppresses expression of the meiosis-specific transcription factor Mei4 and maintains the inactive state of CDK through Mik1/Wee1 to coordinate the progression of meiosis.

This third phenotype includes errors in mitotic chromosome segregation, activation of, but failure to sustain, the spindle assembly checkpoint, decreased expression of Aurora B, and a high rate of failure to complete cytokinesis.