Sentence examples for checkpoint defect from inspiring English sources

The precise physiological role of H2AX phosphorylation is not yet fully understood, but cells derived from H2AX−/− mice display moderate radiosensitivity [9], [10] and a G2/M checkpoint defect [11].

Cells from mice that lack the H2AX gene manifest a G2/M checkpoint defect similar to that in ATM-deficient cells exposed to low doses of ionizing radiation (12).

In addition to the checkpoint defect in swi3-NBT7, E40 and E31, these cells showed strong accumulation of spontaneous Rad22 DNA repair foci, indicative of DNA damage (Figure 6B).

This suggests that the failure to bring Mad1 Mad2 to kinetochores causes the checkpoint defect.

When the two inhibitors were combined, each at 100 nM, a dramatic checkpoint defect was exposed.

We propose that the checkpoint defect imposes an additional mechanism of sensitivity on cells.

However, when cell cycle checkpoint defects are combined with defective DSB repair, the impact is more than additive, consistent with the notion that cell cycle checkpoint arrest enhances the opportunity for DSB repair.

The late atm phenotype might also be due to defective repair in addition to early cell cycle checkpoint defects.

Cells with telomere capping defects containing MRC1 or mrc1 AQ, a checkpoint defective allele, exhibit similar growth, suggesting growth defects of cdc13-1 mrc1Δ are not due to checkpoint defects.

Spindle checkpoint defects are associated with resistance to taxanes and vinca alkaloids.

BRCA1 dysfunction is closely related to spindle checkpoint defects but not to G2 phase alterations.