Cellular checkpoint control using programmable sequential logic.
Detailed investigations revealed that GO-PEG-PEI could cause genomic DNA damage, activating the intra-S-phase checkpoint control via both the ATM and the ATR signaling pathways.
Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS ONE 2(11): e1165.
Peng, C. Y. et al. Mitotic and G2 checkpoint control: regulation of 14.3.3 protein binding by phosphorylation of Cdc25C on S216.
Boisvert, F.-M., Déry, U., Masson, J.-Y. & Richard, S. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.
Presumably, DNA damage can block cells to enter the S phase due to the presence of checkpoint control that inhibits the initiation of replication36,37.
Janke, C. et al. The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control.
Consequently, the CHK1 level available in the nucleus for phosphorylation and activation by ATM/ATR23 is reduced, thus impairing G2/M checkpoint control after IR (Fig. 4A C).
Klein, H.L. Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Δ with other DNA repair genes in Saccharomyces cerevisiae.
The study of biological responsiveness to DNA damage embraces DNA repair, mutagenesis, damage tolerance, cell-cycle checkpoint control, programmed cell death, and other cellular responses to genomic insult.
Bin, W., Hurov, K., Hofmann, K. & Elledge, S. J. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
