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Each checkpoint consists of a signal, which is detected by signal sensors that activate signal transduction pathways, which in turn modify targets to produce an output.
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Another mechanism involved in intra-S checkpoints consists of the direct phosphorylation of CHK2 (T68) by ATM, which can facilitate CHK2 interactions with other proteins, such as BRCA1 and 53BP1 [ 131].
A second set of proteins is required with Mec1 to initiate the DNA damage checkpoint and consists of a clamp (the Rad17 Mec3 Ddc1 complex) and a clamp loader (Rad24 RFC) (Majka et al, 2006).
The DNA damage checkpoint response consists of a signal transduction cascade mainly based on phosphorylation events; the mechanistic details of the pathway have been recently discussed elsewhere [15,16], and will be just briefly summarized here to give a schematic picture to the reader.
One reason the lines get so long is that everyone has to funnel through a single makeshift Egyptian Army checkpoint, which consists of an American-made tank on one side and barbed wire on the other.
The award consists of a bronze medal.
Surgical equipment consists of a few scissors.
Instrumentation consists of a piano.
"Each galaxy consists of a hundred billion stars.
Hair consists of a protein-based keratin.
The pointer consists of a thumbscrew.
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