Exact(2)
Each checkpoint condition is translated into a group of specific sequences of state transitions that can be derived by ordering pairs of state transition among Clb2, Cdc20 and their interacting genes.
In particular, such models violate the M phase checkpoint condition so that it allows a division of a budding yeast cell into two before the completion of its full DNA replication and synthesis.
Similar(58)
It violates the property 4 of the M-metaphase checkpoint conditions (see Additional file 1).
Over the last decade, there have been several studies to construct Boolean models that capture checkpoint conditions.
The cell cycle can proceed to the next phase properly only if checkpoint conditions are met.
The proposed model is the timing-robust model that properly preserves all the essential checkpoint conditions against timing variations.
We derived the logical properties to check from essential checkpoint conditions of the budding yeast cell cycle.
In this study, we present a timing-robust model that properly preserves all the essential checkpoint conditions against timing variations.
Only recently, some studies suggested extension of such models towards timing-robust models, but they have not considered checkpoint conditions.
In this paper, we present a timing-robust model that preserves all the essential checkpoint conditions properly against timing variations.
The cell cycle can proceed to the next phase properly only if the above checkpoint conditions are satisfied.
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